The purpose of this review is to motivate the quantitative study of biological porous tissues where fluids and structures are interacting; this will brings two fields into focus Poroelasticity (PE) and Fluid-Solid Interaction (FSI). Both fields were initiated few decades ago and have been growing but received little attention in funding and research. PE focuses on deformation of porous medium that is saturated with fluid and it lies in the intersection of elasticity, solid mechanics, fluid mechanics, and continuum mechanics while FSI lies in the intersection of fluid mechanics, solid mechanics and dynamics. What has been impossible few decades ago is possible to do today with latest development in computational techniques and technology. This development have resulted in emerging of new research fields [1] – [6]. The new frontier will compel researchers to grasp fundamentals with depth in physics, biology, mathematics and engineering. The significance of the work is the potential to lead to development of new smart materials based on biological concepts. Honey comb beams and structures were developed from nature and they are widely used today in many applications including aerospace. More studies on poroelastic behavior of biological tissues can lead to a break through in materials science. Also, further research in PE and FSI will push the limits of knowledge in mechanics and quantitative analysis of biological tissues and determination of their mechanical properties. Furthermore, the research will improve our knowledge about current challenges such as osteoporosis, arthritis, failure of artificial heart valve, medical implants, and artificial limbs.

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